We find that there are 516 approved drugs targeting GPCRs, making up 36% of all approved drugs. These drugs act on 121 GPCR targets, one-third of all non-sensory GPCRs. Furthermore, 337...

Jan 1, 2024 · G-protein-coupled receptors (GPCRs) are the largest and most versatile cell surface receptor family with a broad repertoire of ligands and functions. …

Apr 17, 2025 · G protein-coupled receptors (GPCRs) remain one of the most valuable and versatile classes of drug targets in modern medicine. This blog explores the evolving landscape of GPCR drug …

Dec 4, 2023 · Their diverse and essential roles in the body make them a significant focus for pharmaceutical research and drug development. Currently, approximately 35% of marketed drugs …

Jan 11, 2025 · Altogether, this tool informs of 162 the current status of specific GPCRs as drug targets pinpoints both those being re-targeted and entering 163 clinical trials for the first time.

A pharmacogenomic analysis probes the effects of genetic variation in G-protein-coupled receptors on responses to FDA-approved drugs and estimates how this genetic variation may impact healthcare …

GPCRs are the largest family of proteins involved in membrane signal transduction and are also the most intensively studied drug targets, largely due to their substantial involvement in human …

Nov 10, 2021 · In this article, signaling pathways, the structure of GPCRs and the development pattern of different stages of targeted drugs are covered.

May 23, 2022 · GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug target class. This is underlined by the fact that …

Mar 3, 2025 · We find that there are 516 approved drugs targeting GPCRs, making up 36% of all approved drugs. These drugs act on 121 GPCR targets, one-third of all non-sensory GPCRs. …