Documentation strongly suggests the interaction exists, but well-controlled studies are lacking. The interaction may result in an exacerbation of the patient’s condition and/or require an …

ICH is a consensus-driven process that involves technical experts from regulatory authorities and industry parties in detailed technical and science-based harmonization work that results in the...

You are concerned that this patient may be at increased risk of drug interactions and want to intervene to prevent any negative adverse effects. Explain why this patient may be at an …

Try to avoid both or at least consume small amounts.

To address these issues, we modified the surface of a zinc anode with a functional bilayer composed of zincophilic Cu and flexible polymer layers. The zincophilic Cu interfacial layer was …

Interrupt dosing for severe neutropenia. In CLL, resume at same or reduced dose.

This question and answer (Q&A) document is intended to provide additional clarification and improve harmonization of drug interaction assessment.