For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

Mitochondria are dynamic organelles, the morphology of which results from an equilibrium between two opposing processes, fusion and fission. Mitochondrial fusion relies on dynamin‐related GTPases, the ...

Activation of cell death pathways typically leads to the irreversible destruction of the cell. However, in this issue of The ...

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Centriole duplication relies on precisely timed engagement and disengagement of mother and daughter centrioles. This study reveals the multimodal, cell cycle-dependent mechanisms coordinating ...

Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side ...

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...

Clustered regularly interspaced short palindromic repeat (CRISPR) is a recently discovered adaptive prokaryotic immune system that provides acquired immunity against foreign nucleic acids by utilizing ...

Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well‐established roles in ...

References and Citations As a matter of policy, the journal requires the citation of primary literature (over review articles) and, when appropriate, of data (see section on Data citation below). The ...

The resident prokaryotic microbiota of the metazoan gut elicits profound effects on the growth and development of the intestine. However, the molecular mechanisms of symbiotic prokaryotic–eukaryotic ...