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For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...
The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...
EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...
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During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...
Treatment of sensitive bacteria with beta‐lactam antibiotics often leads to two salient population‐level features: a transient increase in total population biomass before a subsequent decline, and a ...
While SMAD7 has been widely studied in liver and kidney fibrosis—where it dampens TGF-β activity and restrains inflammation-driven ECM accumulation—recent evidence highlights its relevance in cardiac, ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. I am an adult “third culture kid”, the child ...
NF2 deficiency eliminates LATS-mediated phosphorylation of YAP, allowing dephosphorylated YAP to enter the nucleus and co-activate CAD and DHODH transcription. Together, these enzymes accelerate de ...