SMA is a motor neuron disease characterised by generalised muscle atrophy and weakness. It is caused by the dysfunction and eventual death of motor neurons, due to deletions of SMN1 in 95% of patients ...

Adrenal insufficiency (AI) is characterised by lack of cortisol production from the adrenal glands. This can be a primary adrenal disorder or secondary to adrenocorticotropic hormone deficiency or ...

Paediatric early warning systems (PEWS) to reduce in-hospital mortality have been a laudable endeavour. Evaluation of their impact has rarely examined the internal validity of the components of PEWS ...

The hierarchy of evidence in assessing the effectiveness of interventions or treatments is explained, and the gold standard for evaluating the effectiveness of interventions, the randomised controlled ...

The presentation of a neonate with poor feeding and respiratory distress is a common paediatric scenario. While acute myocarditis is an uncommon cause of this presentation, rapid recognition and ...

Background Despite the increased policy attention on ethnic health inequities since the COVID-19 pandemic, research on ethnicity and healthcare utilisation in children has largely been overlooked.

Objective To evaluate the cost-effectiveness of planned observation on cranial CT use in children with minor head trauma. Design Planned secondary analysis of a multicentre prospective observation ...

Context There is a dearth of high-quality evidence on integrated, coordinated and cost-effective care for children with special health and care needs (CSHCN). Objective To assess the effectiveness of ...

Background The use of patient-facing health technologies to manage long-term conditions (LTCs) is increasing; however, children and young people (CYP) may have preferences about health technologies ...

Objective According to international guidelines, children with enuresis are recommended urotherapy, or basic bladder advice, before treatment with evidence-based alternatives such as the enuresis ...

Noonan syndrome (NS) is a mostly dominantly inherited disorder affecting 1:1000 to 1:2500 live births. The phenotype varies in severity and can involve multiple organ systems over a patient’s lifetime ...

There are at least 12 paintings from the late 17th to the early 20th centuries titled, ‘The Sick Child’. They were painted by well-known and obscure artists from Holland, Norway, France, England, ...