BACKGROUND: Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multisystem end-organ ...

BACKGROUND: Direct reprogramming of fibroblasts to cardiomyocytes is a potentially curative strategy for ischemic heart ...

Cardiovascular disease (CVD) mortality increased by 78%, rising from 72.4 to 128.7 per 100 000 (2017–2022), with the greatest ...

Explore the latest research and articles in Circulation Research, featuring high-impact studies and reliable findings for the scientific community.

Using the Global Burden of Disease 2021 data, we analyzed the prevalence and disability‐adjusted life years, examining implications across demographics and geographic regions. In 2021, an estimated 54 ...

BACKGROUND: Evaluation of whether dyspnea has a cardiac cause is essential. Guidelines from 2016 were reported to result in a ...

We read with great interest the article by Duan et al, 1 which found that BMP9 (bone morphogenetic protein 9) is protectively expressed in humans and mice with myocardial infarction (MI). BMP9 ...

Cardiovascular-kidney-metabolic (CKM) syndrome is a novel construct recently defined by the American Heart Association in response to the high prevalence of metabolic and kidney disease.

Herein we report results of the 1-year, double-blind, placebo-controlled part of the phase 3 study ORION-13 (Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial ...

In this American Heart Association scientific statement, we aim (1) to explore the definitions and conceptual framework of palliative care, (2) to review data supporting its use in noncardiac and ...

Chronic coronary disease (CCD) is the leading cause of death in the United States. There is an ongoing imperative to disseminate evidence-based and patient-centered care recommendations that further ...

Since then, additional evidence associating and causally linking sleep to CMH has accumulated. As a result, in 2022, the American Heart Association added sleep duration as an eighth metric of CMH, ...