As you can see, Christian McCaffrey is not listed anywhere and will play, despite having a back injury and suffering from an illness earlier in the week. We’ll see if Kyle Shanahan lightens the workload for McCaffrey, but that has never been his style. Whenever McCaffrey plays, he’s the workhorse.

Updated inactives and analysis based on the latest reports and official announcements leading up to kickoff.

Injuries are again piling up for Week 15 of the 2025 NFL season, including at quarterback

Christian McCaffrey is still one of the 49ers' best operators.

Considering how these teams match up, selecting player prop bets wasn't hard this week. Here are the three best player prop bets from this Week 15 matchup, per BetMGM. Anytime tou

The 49ers are 12.5-point favorites, per the latest Titans vs. 49ers odds, and the over/under for total points scored is 44.5 at DraftKings. The 49ers are -901 money line favorites (risk $901 to win $100),