The San Francisco 49ers made a significant decision on wide receiver Brandon Aiyuk that could spell the end of his tenure in the Bay Area.

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to win the Week 15 NFL game.

In the past month, they’ve faced three of the top four teams per defensive DVOA and averaged 22.6 points scored in those games. That’s good going when they’ve averaged just 15.5 points across the whole season. The 49ers are averaging 23.6 points per game, and with the Titans showing real signs of improvement, we should see the game total smashed.

The San Francisco 49ers could face a major setback when the 2025 NFL season ends, as Robert Saleh might be on a team's radar for head coach.

The San Francisco 49ers have been valued at more than $9bn after the chairman of artificial intelligence behemoth OpenAI agreed to acquire a stake in the NFL franchise. Bret Taylor – who is also the co-founder and chief executive of fellow AI business Sierra,