My favorite use for the middle mouse button: double-click. In other words, instead of having to manually double-click a desktop icon to launch a program or open a document, I just middle-click it.

X-Mouse Button Control for Windows 11/10 lets you remap your mouse buttons differently for different software. Download it free.

Logitech wheel mouse. Pressing wheel used to act as double click. Quit doing that. installed X-Mouse Button Control program and functioned as i wanted. Then it quit working again. Tried ...