Classical regression analysis is usually performed in two steps. In a first step an appropriate model is identified to describe the data-generating process and in a second step statistical inference ...

The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.

We propose a sequential approach for constructing multiple-objective locally optimal designs for nonlinear models. The technique used here is a general one and we demonstrate the added benefits of ...