Boltz-2 is the first biomolecular co-folding model to combine structure and binding affinity prediction, approaching the accuracy of physics-based free energy perturbation (FEP) calculations but ...

As Recursion increased the size of the training data and the number of model parameters, the model's performance increased, demonstrating a need for ample compute to train larger models.

Boltz-2’s development was led by the Boltz team at MIT under the supervision of Professors Regina Barzilay and Tommi Jaakkola alongside a team of researchers from MIT and Recursion.