While you don’t necessarily need a Pyboard in order to use MicroPython, the microcontroller is one of the best and easiest to work with when it comes to hardware programming.

Slimmed-down version of Python, rebuilt from the ground up, is designed to run fast and lean on microcontroller hardware The Python programming language’s flexibility and ease-of-use have made ...

While the writeup is only about blinking a LED with a microcontroller, they’re doing it with Python, interactively, and at runtime. The build uses the Maple Native board the team is developing.