Here we identify PML as a critical inhibitor of neoangiogenesis (the formation of new blood vessels) in vivo, in both ischaemic and neoplastic conditions, through the control of protein translation.

PML and PML-NBs have been implicated in the regulation of growth inhibition, senescence and apoptosis. PML is activated in response to stress signals and is downregulated in certain human cancers.

Biogen Idec and Elan reported to the SEC that another case of PML has been seen with natalizumab therapy in a patient with MS. The case was found through surveillance, the companies note, and the ...

Because the first sign of PML was seen in new MRI findings, this case report underlines the value of surveillance imaging in patients receiving natalizumab, researchers say.