You can embed a PDF file into a cell of an Excel worksheet and then use Excel's security features to lock the object. This allows you to take advantage of both technologies.

Microsoft announced this week that's it's now possible for Office 365 users to import table data from Adobe Portable Document Format (PDF) files into the Microsoft Excel spreadsheet program.

How to Copy Format Changes From One Table to Another in an Excel Spreadsheet. Microsoft Excel lets you format tables, adding borders and colors, and lets you format the text in them, editing font ...