The team's new model is a 3D human neuroimmune axis model is comprised of stem-cell derived neurons, astrocytes and microglia along with peripheral immune cells.

In a three-dimensional culture system, neurons expressing AD mutations activated glia. CD8+ T cells infiltrated the culture. When both CD8+ T cells and microglia were present, neurodegeneration ensued ...

3D cell model imaging and analysis workflows provide more physiologically relevant insights but are not without their challenges. This guide explores how researchers can make the most of the latest 3D ...