How to compare columns in Microsoft Excel As stated, we can use the Excel VLOOKUP function to find and match different data or find differences in two columns.

Microsoft Excel is perhaps the most powerful spreadsheet application you can buy. But it also has some simple functions, like finding duplicates in data.

Choose your desired color format for emphasizing duplicates and confirm with OK. There are several different methods to handle the duplicates, but using Excel's built-in tool is the easiest.