If multiple users work in the same Microsoft Excel file, you can limit their access to only the ranges where they need to work.

With the Excel file open select File in the top-left corner of the screen, followed by Info. Select Protect Workbook, then choose Encrypt with Password.

How to Use an Excel Workbook Over a Network. Microsoft Office Excel 2010 workbooks can contain dozens of different spreadsheets, and each one can contain an entire database.