When drug development and the immune system collide we get CAR-T, checkpoint inhibitors, oncolytic vaccines, monoclonal antibodies and more. These fields have produced many therapies and garnered a ...

It was called ‘complement’ because it aided the antibacterial activity of antibodies. However, it is now known that the complement system can be activated early in an infection without the presence of ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 2 (Jan. 19, 1999), pp. 628-633 (6 pages) Decay-accelerating factor (DAF) is a glycosylphosphatidylinositol ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 2 (Jan. 15, 1992), pp. 628-632 (5 pages) The role of a viral gene product in evasion of the host immune ...

“After more than a decade of groundbreaking research targeting the early classical complement pathway, we are excited to have reached an important step in the clinical development of ANX1502, our ...

The current coronavirus disease 2019 (COVID-19) pandemic, which is due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 5.5 million casualties to date. Despite ...

Target Levels of Active Drug Achieved in Healthy Volunteers with Oral Twice-Daily Dosing; Supportive Impact on Pharmacodynamic Biomarker of Complement Activity ANX1502 Generally Well Tolerated Across ...