The aim of this study was to assess the effects of buffer systems (bicarbonate or phosphate at different concentrations) on the in vitro dissolution profiles of commercially available enteric-coated ...

PURPOSE:The aim of this study was to examine if sparging with CO2(g) could be used to establish stable biorelevant bicarbonate buffers, in aqueous medium, for use in dissolution characterization of ...

University of Michigan, College of Pharmacy, Department of Pharmaceutical Sciences, 428 Church Street, Room 4002, Ann Arbor, Michigan 48109, United States ...

Researchers have identified this receptor in brain mural cells that regulates reperfusion injury. Optimal pH homeostasis for cellular function is maintained by the acid-base balance through multiple ...

GPR30 in brain microvasculature responds to bicarbonate, and its deficiency protects against ischemia-reperfusion injury, reducing neurological deficits and blood-brain barrier disruption. These ...

Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan Department of Biochemistry, Juntendo University Graduate School of Medicine, Tokyo ...

Internal acid–base homeostasis is fundamental for maintaining life. Accurate and timely interpretation of an acid–base disorder can be lifesaving, but the establishment of a correct diagnosis may be ...