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The trick? On some Nano boards and clones, the bootloader is set to use a large block of reserved memory, but Optiboot only requires a fraction of that reserved memory.
The Raspberry Pi Pico is both faster and cheaper than the Arduino Nano, but the nano has better resources and community.
The Arduino Nano uses a bootloader for handling programming the MCU, which requires the USB to serial bridge to be disconnected from anything that could interfere with the programming.
Available to purchase for £8 or $8 depending on your location the Maker Nano RP2040, as the name suggests, features a Arduino Nano form factor and is powered by a Raspberry Pi RP2040.