GPIO (and therefor I2C) cannot be used at 5v. You will need to use a level shifter on the I2C lines if you want to run the board at 5v. Connections on Raspberry Pi Pico board, other boards may vary.

This project demonstrates how to use a Raspberry Pi Pico W as a web server to control and display messages on an I2C LCD. By accessing the web interface, users can input text, which is then displayed ...

While the Raspberry Pi has very good support for an I2C bus, a lot of very cool chips – including the in system programmer for just about every ATtiny and ATmega microcontroller – use an SPI ...

As for UARTs, the Raspberry Pi’s one-and-a-half UART interface has long been an issue in robotics and home automation applications.

Makers, developers and hobbyists that enjoy using the Raspberry Pi mini PC to build projects or are using the single board PC to learn more about coding, may be interested in a new simple LCD ...