Jupyter Notebook installation and setup The easiest way to create and work with Jupyter Notebooks for Python is to set up an instance of the Anaconda distribution of Python.

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As someone who often works with Python scripts, Jupyter Notebook is my favorite tool for making notes during lectures and sharing my painstakingly-written code with my programming friends and rivals.

On the other hand, PyXLL-Jupyter operates locally, on your device. This gives you total control over your Python environment and data.