Ryan served up a two-out, two-run home run to Shea Langeliers in the third right after issuing a four-pitch walk to Nick Kurtz, turning the Twins’ lead into a deficit, and then found himself in more trouble an inning later.

After taking the series opener in Minnesota last night the A’s will try to make it two in a row over the Twins, looking to both inch closer to 60 wins while burying the Twins’ dwindling playoff chances.

The A’s built a big lead with a three-run fourth inning, and the Twins couldn’t rally despite home runs from Brooks Lee and Ryan Jeffers.