For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.

The San Francisco 49ers will face the Las Vegas Raiders in week 2 of the NFL preseason on Saturday at Allegiant Stadium.

The Las Vegas Raiders host the San Francisco 49ers at Allegiant Stadium with kickoff set for 4 p.m. ET on NFL Network, with multiple streaming options available.